Idiopathic pulmonary haemosiderosis (IPH)

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Idiopathic pulmonary haemosiderosis revisited.

Idiopathic pulmonary haemosiderosis is a rare cause of diffuse alveolar haemorrhage of unknown aetiology. It occurs most frequently in children, has a variable natural history with repetitive episodes of diffuse alveolar haemorrhage, and has been reported to have a high mortality. Many patients develop iron deficiency anaemia secondary to deposition of haemosiderin iron in the alveoli. Examinat...

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Idiopathic pulmonary haemosiderosis in children.

Idiopathic pulmonary haemosiderosis (IPH) was first described by Virchow in 1865 as 'brown lung induration'. In 1931 Ceelen reported the necropsy findings in 2 children. The clinical picture in association with radiological and pathological findings was reported by Waldenstrom (1944), and Wyllie et al. (1948) reviewed 24 cases in children. Nearly 200 have since been reported. In the past 5 year...

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Chloroquine in idiopathic pulmonary haemosiderosis.

Two cases of idiopathic pulmonary haemosiderosis are reported in order to highlight the diagnostic problems, associated features, and the response to chloroquine, which is a new treatment for this life threatening condition. Iron deficiency anaemia is common in childhood and usually dietary in origin.' If a deficient intake is not the cause, diagnostic attention normally focuses on the gastroin...

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Idiopathic pulmonary haemosiderosis and smoking.

Idiopathic pulmonary haemosiderosis is a rare condition usually affecting children and young adults, both male and female. It is characterised by intermittent episodes of pulmonary haemorrhage producing haemoptysis, iron deficiency anaemia and in its early stages a rise in KICO (transfer factor per unit of alveolar volume). Electron microscopic studies have demonstrated damage to the capillary ...

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Idiopathic pulmonary haemosiderosis in a newborn.

A male infant of 3 kg. was born of a normal pregnancy. Following his discharge from hospital a week after birth, his mother found that he was breathless and slow to feed. He was examined the following week and the only abnormality found was hypotonia. When 31 weeks old he developed oedema of the extremities, followed 3 days later by generalized oedema. On admission he was exhausted, generally h...

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ژورنال

عنوان ژورنال: Respiratory Medicine

سال: 1995

ISSN: 0954-6111

DOI: 10.1016/0954-6111(95)90146-9